Biochem/physiol Actions

≥7500 units/mg

General description

An antibiotic that inhibits phospholipid sensitive Ca²⁺-dependent protein kinase. Mixture of polymyxin B₁ sulfate and polymyxin B₂ sulfate. Binds to cell wall and makes it more permeable, causing fluid uptake. Effective against Gram-negative bacteria.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Lucas, M., et al. 1994. Biochem. Pharmacol.47, 667.Ngezahayo, A. and Kolb, H.A. 1993. Pflugers Arch.422, 413.Kubo, M. and Okada, Y. 1992. J. Physiol.456, 351.Strasser, R.H., et al. 1992. Circ. Res.70, 1304.Hegemann, L., et al. 1991. Eur. J. Pharmacol.207, 17.Inaba, H. and Finkins, J.P. 1991. Am. J. Physiol.261, R26.Marra, M.N., et al. 1990. J. Immunol.144, 662.

Packaging

20 ml in Plastic ampoule

Physical form

Supplied at 50 mg/ml in H₂O.

Reconstitution

Following initial thaw, aliquot and freeze (-20°C).

Warning

Toxicity: Harmful (C)