Biochem/physiol Actions
≥7500 units/mg
General description
An antibiotic that inhibits phospholipid sensitive Ca2+-dependent protein kinase. Mixture of polymyxin B1 sulfate and polymyxin B2 sulfate. Binds to cell wall and makes it more permeable, causing fluid uptake. Effective against Gram-negative bacteria.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Other Notes
Lucas, M., et al. 1994. Biochem. Pharmacol.47, 667.Ngezahayo, A. and Kolb, H.A. 1993. Pflugers Arch.422, 413.Kubo, M. and Okada, Y. 1992. J. Physiol.456, 351.Strasser, R.H., et al. 1992. Circ. Res.70, 1304.Hegemann, L., et al. 1991. Eur. J. Pharmacol.207, 17.Inaba, H. and Finkins, J.P. 1991. Am. J. Physiol.261, R26.Marra, M.N., et al. 1990. J. Immunol.144, 662.
Packaging
20 ml in Plastic ampoule
Physical form
Supplied at 50 mg/ml in H2O.
Reconstitution
Following initial thaw, aliquot and freeze (-20°C).
Warning
Toxicity: Harmful (C)
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